Recent research has shown the optimum time to take Carbo blocker is just before a starch-rich meal along with 8 oz of water. However, the studies also showed that it could still provide some of its starch "neutralizing" benefits when taken during, or just after, a starch-rich meal. One such study demonstrated that Phase 2® Carbohydrate blocker could remain effective when a capsule is opened and sprinkled onto food.