How Lithium Orotate Works

How does lithium orotate work?

Lithium orotate releases the lithium ion into the plasma and brain just like pharmaceutical lithium carbonate and lithium citrate. This is exactly the same way prescription lithium works, albeit without the toxicity.

Lithium orotate, mania, norepinephrine

Lithium orotate also reduces norepinephrine by reducing sensitivity in the postsynaptic norepinephrine receptor. Less sensitive, the receptor is less likely to receive norepinephrine and less norepinephrine transfers throughout the body. Lithium orotate also increases the uptake of norpinephrine into synaptosomes. Synaptosomes are pinched off nerve endings that cannot release hormones such as norpinephrine. Though it is known to reduces norpinephrine is remains unknown as to exactly how this comes about. Less norpinephrine reduces mania (Van Praag, 1977).

Lithium orotate, mania, dopamine

A paper published in the January 11th issue of Cell, a Duke Medical Center team has found that lithium interrupts the signaling of one of the D2 dopamine receptors in the brain. Elevated dopamine causes people to act impulsively and erratically. Lithium orotate, citrate, carbonate also inhibits the glycogen synthase kinase 3 (GSK-3) enzyme which is important in the cell's response to many signaling molecules. By destabilizing the D2 / GSK3 signaling pathway complex mania is reduced.

lithium orotate, bipolar, omega oils: synergy

Current research has provided clear evidence that lithium reduces brain inflammation by recalibrating DHA—healthy Omega 3 fatty acid. Anyone diagnoses with bipolar disorder should seriously consider a steady diet of omega acids via supplementation or fish, flax and nut diet. The National Institute of Aging examined brain samples via mass spectrometry analysis demonstrated how a six-week lithium treatment reduced inflammatory arachidonic acid levels. They also discovered that lithium the 17-OH-DHA metabolite formed from the omega-3 fatty acid is also the precursor to a wide range of anti-inflammatory compounds known as docosanoids. (Aspirin, the most popular anti-inflammatory protocol, has been shown to enhance docosanoids). Omega oil DHA concentration did the opposite. By reducing both pro-inflammatory arachindonic acid and docosanoids and increasing anti-inflammatory DHA, lithium can exert a double-protective effect creating a powerful synergy against bipolar affliction.

Lithium Orotate and Mitochondria

Lithium Orotate benefits manic depression in the human body by facilitating lithium absorption into the mitochondria—the powerhouse of our cells. Natural lithium, Lithium orotate, also stabilizes lysosome membranes which attenuates the enzymatic reaction that induce negative side effects characteristic of other forms of lithium. Lithium Orotate is not a drug, it is a naturally occurring mineral, like calcium and sulfur. Like any other mineral lithium is a fundamental requirement for mental and physical health. Most people are only aware of the pharmaceutical forms of lithium (lithium carbonate and lithium citrate) for the treatment of bipolar disorder and bipolar mania. Lithium Orotate is very different than these other forms of the mineral which require high doses to penetrate our cells. Lithium Orotate has over a 90% absorption rate so extremely low doses are needed to be effective. Lithium Orotate via nasal form is even more absorbable. It penetrates faster and given the advanced delivery system requires smaller doses. Moreover, Symmetry is designed to help the body to release more of your own lithium, an even healthier way to go. There are no side effects.