In 1996 a team of Swedish scientists discovered why HGH replacement makes so many people feel good.  They found it acts on the brain just like an antidepressant, raising the level of the neurotransmitter B-endorphin, which has been called the brain's opiate.  HGH also lowers the level of dopamine, which is associated with feelings of agitation.  Other reports indicate that increased levels of HGH reduce stress, improve focus and concentration, and build self-esteem and self-confidence.  A 1998 report showed that depressed men have a marked decrease in HGH secretion during the first three hours of sleep as opposed to non depressed controls.  Indeed, higher levels of HGH induced a more restful and sounder sleep.

Three different studies in Sweden, Denmark, and England reported that HGH replacement therapy had dramatic, positive effects on patients suffering from low self-esteem, anxiety and depression.

In a report by L. Cass Terry, M.D., Ph.D. to the American Academy of Anti-Aging Medicine in December 1996, Dr. Terry reported that his clinical group of 900 people, 300 or which were doctors, 80% experienced improved attitude toward life, and 67% experienced enhanced emotional stability.

A recent clinical study by Theirry Hertoghe, M. D. showed that HGH therapy decreased depression by 82% and anxiety and low self-esteem by over 70%.

Adult-onset growth hormone deficiency (GHD) often experience a sub-optimal quality of life (QoL), impaired cognition, and reduced psychosocial functioning. In fact, studies of patients with adult-onset GHD consistently found a lack of energy and emotional problems as being characteristic of this population. Memory lapses, difficulty concentrating, and forgetfulness are frequently reported by patients with adult-onset of GHD. Moreover, when compared to patients with diabetes mellitus, one study found increased psychiatric illness, depression, and dysthymia among adults with hypopituitarism. (The essential feature of Major Depression is one or more Major Depressive Episodes without a history of either a Manic Episode or an unequivocal Hypomanic Episode. The essential feature of Dysthymia is a chronic disturbance of mood involving depressed mood for most of the day more days than not. In addition, during these periods of depressed mood there are some of the following associated symptoms: poor appetite or overeating, insomnia or hypersomnia, low energy or fatigue, low self-esteem, poor concentration or difficulty making decisions, and feelings of hopelessness. This has often been referred to as Depressive Personality.)

These problems tend to be reported more by growth hormone-deficient women than men, and are more prevalent in patients with long-standing disease than in those recently diagnosed with GHD. Overall, adults with untreated hypopituitarism tend to report a lower health status than the general population.

Data from a study conducted by the Lee-Benner Institute’s longitudinal trial using GH to treat Somatopause (disorders of body composition and function resulting from a more or less rapid decline of GH secretion that is seen with increasing age) for 1,521 patients with adult-onset GHD demonstrated that improvements from the baseline in total score, energy levels, and emotional reaction using the NHP persisted after 10 years of treatment. Even this instrument, which tends to underestimate the extent of QoL impairment , shows the dramatic long-term improvement associated with GH therapy.

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