A strain of mice genetically bred to be nervous has been developed by
a researcher who hopes the reticent rodents can provide answers
about human anxiety. Dr. Laurence Tecott of UC San Francisco created
the anxious mice by blocking a gene for a specific serotonin receptor
called 5HT-1A.
  Serotonin, a protein that serves as a neurotransmitter in the brain, has
been found to affect anxiety, depression and eating behavior in animals
and humans. Serotonin receptors hold the serotonin protein on different
cells and allow them to communicate with one another. But scientists
have found so many serotonin receptors in the brain-14 at last count
that they are trying to figure out what role each of the receptors plays in
regulating behavior and emotion.
  "We want to develop a mouse psychiatry," Tecott said. His mice are
skittish, nervous and reticent, a perfect model of the kind of human
anxiety that plagues millions.

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