ProBiotics studies

The Effects of stress on the gut microflora
 



Probiotics Ease Gut Problems Caused By Long Term Stress

Stress affects the parts of the body related to the nervous system, especially the gastrointestinal tract. Emotional breakups, ill loved ones, pressures at work, mounting bills . . . whatever the cause, emotional stress causes an increase in adrenaline, which triggers a release of stored sugar from your liver.

In response to this adrenaline rush, blood is diverted from your intestines to your muscles, which causes a dramatic slowdown of your digestive processes. Chronic stress compromises the health of your friendly bacteria. If this pattern continues over a long period of time, the most obvious effects occur in the large intestine.

In sufficient strength, the friendly lactobacteria can indirectly help in alleviating stress. During fermentation, lactobacilli release essential amino acids, including tryptophan. Tryptophan produces serotonin—a calming neurotransmitter. Probiotics literally compete for space with harmful bacteria and dampen down inflammatory responses, and as such, offer a potentially promising approach to the management of intestinal problems caused by stress. Click here to read more.

Probiotics may help to reduce gut symptoms caused by long term stress, indicates research published ahead of print in the journal Gut.
The researchers base their findings on analysis of gut tissue taken from rats subjected to either water avoidance stress, which involves placing the rat on a small platform surrounded by water, or sham stress for one hour a day for 10 consecutive days. The stress sessions were designed to mimic psychological stress to produce the type of effects that would be seen in the human gut. Half the rats were fed drinking water containing probiotic bacteria in the form of Lactobacillus helveticus and Lactobacillus rhamnosus for a period of seven days before and during the stress sessions.

Unlike sham stress, brief but repeated water deprivation made the gut "leaky" and boosted the adherence of harmful bacteria to the cells lining the gut wall. Bacteria were also detected in the mesenteric lymph nodes, which drain fluid coming from the intestine, indicating that bacteria had entered the body and activated the immune system.

However, probiotic treatment minimized the changes in chemical signalling and prevented bacterial "stickiness" and movement to the mesenteric lymph nodes. Chronic stress is known to be implicated in the development of irritable bowel syndrome and in the worsening of symptoms of inflammatory bowel disease, such as Crohn's disease and ulcerative colitis. It also sensitizes the gut, producing allergies to certain foodstuffs.

The authors say that probiotics literally compete for space with harmful bacteria and dampen down inflammatory responses, and as such, offer a potentially promising approach to the management of intestinal problems caused by stress.