Accept no substitutes. There are more than 370 species of the genus Hypericum. (St. John's wort), several of which are not pharmacologically active. Not all St. John's wort is equal. The vast majority of OTC St. John's wort formulations are made with aerial parts, AKA “Grind”, whole ground up plant, not the small red and white dots in flowers that contain the precious napthrodianthrones. Grind does not contain hyperforin. Of even greater concern, grind contain zanthrones found in the stems which are the source of the controversial MAO inhibitors. MAO inhibitors were the number one cause of drug overdoses in the early days of prescription antidepressants. NIH research indicates that St. John's wort must contain both hypericin and hyperforin if is to be an effective mood modulating protocol. Hyperforin is only found in its red and white dots in the flowers.

Harvesting high hyperforin SJW is critical (At point of harvest, the higher the hypericin, the lower the hyperforin and vis a vis). Extracting high quality hyperforin is difficult and costly. First the plant must be of superior quality, preferably grown in non-phosphate fertilizers. Upon harvest the flowers must be carefully dried so the hyperforin can be extracted via methanol extraction process. hyperforin is a notoriously delicate substance and can easily be destroyed by exposure to oxygen, heat and moisture which is why HBC Protocols folds in a broad spectrum grape seed antioxidant to stabilize its hyperforin.

Beware of false hyperforin claims. HBC's St. John's wort contains a minimum of 3% hyperforin but usually much more. It is currently (see Certificate of Analysis) 4.6% hyperforin. Beware of purveyors claiming 5% and higher hyperforin. 5% doesn't exist. If it did we would have it in our formulation. In our 15 years of working with SJW (we were the first to introduce SJW to America) we have never found a 5% hyperforin raw material. Independent lab tests of formulations alleging 5% hyperforin formulations have proven false. As you well know the supplement business in America is not highly regulated which means that just because a company claims 5% doesn’t make it so. Always ask for a Certificate of Analysis

Clinical Research Studies Currently In Progress Using HBC Protocols Hypericum Perforatum

Effect of St. John's Wort
University at Buffalo

Effect of St. John's Wort on Oral Contraceptives
NIH/Columbia University

Efficacy of St. John's Wort for Smoking Cessation
Martin Mahoney, M.D., Ph.D

Effects of St. John’s Wort on Women Receiving Estrogen
University of Illinois 

The Influence of St. John's Wort on the Pharmacokinetics and Protein Binding of Imatinib Mesylate 
New York State Council of Health-System Pharmacists/NIH

St. John’s Wort Effects on Emergency Contraceptive Pills
The University of Utah - College of Nursing

Hypericum & Depression

Can Depression Be Successfully Treated with a Safe, Inexpensive, Medically Proven Herb Available without a Prescription?

Harold H. Bloomfield, M.D.
Mikael Nordfors, M.D.
& Peter McWilliams


Copyright Information
Vital Cautions (Please read this)
A Note about Two Terms Used Often in This Book

Part One: Depression

What Is Depression?
Anne Hedonia

The Undertreatment of Depression

The Treatment of Depression

The Difficulty in Treating Depression

Part Two:

Hypericum Perforatum
Hypericum as Medicine

Part Three:
Hypericum & Depression

The Good News
The Side Effects of Hypericum

The Recommended Dosage of Hypericum

The Young, the Elderly, and the Physically Ill

For Those Currently Taking Prescription Antidepressants

How to Obtain Research-Grade Hypericum

Hypericum, Herbs, and Health Policy

Part Four:
Summaries of Medical Studies on Hypericum and Depression

Scientific Description of Hypericum Perforatum
Studies Comparing Hypericum with Synthetic Drugs

Studies Comparing Hypericum with Placebos

Drug Monitoring Studies

Pharmaceutical Studies

Other Studies

Clinical, Criteria Based Reviews

Author's Comments
About the Authors

Index of Charts & Tables

Depression Medication Catalog

Hypericum Perforatum
Research-Grade St. John's Wort 
300mg - 280 scored tablets

Double .3% Hypericin / 3% Hyperforin Standardized
Click here to view Certificate of Analysis

Each 660 mg. tablet contains a minimum of 300 mg (with a 5 to 10% overage) of Hypericum Perforatum in a clear coat to inhibit moisture degradation. One milligram of grape seed extract has beenadded to protect the hyperforin . Each tablet is manufactured to a minimum Kilopascal hardness of seven, maximum of ten, depending upon humidity. Designed for complete absorption in the upper intestinal tract, its excipients are; Dicalcium phosphate, microcrystalline cellulose, vegetable oil, cross carmellose sodium, magnesium sterate, silicon dioxide. The clear coat is made of hydroxypropylmethylcellulose and polyethylene glycol. Each bottle contains 280, 7/16th round, "Upper bisect" (Scored, should you need to cut them in half) tablets. Taken at the most common research dosage, (3 per day = 900mgs) 280 tablets represents a 93 day supply. The elimination half life of hypericin is 26.5 hours.

St. John's wort's action of mood modulation takes place at the synapsomal level where it works to inhibit the reuptake of three of the four known feel-good neurotransmitters. They are serotonin, norepinephrine and dopamine. Like many of the pharmaceuticals that inhibit the reuptake of only serotonin, this process can take up to 6 weeks to take effect. SJW works more gently and broadly and given that it effects three neurotransmitters is probably why it has such a low side effect profile. However, if you are fair skinned, please exercise caution when going in the sun as you may initially burn. Please click here to read about our liposomally based sunscreen moisturizer.

You will need Acrobat Reader to view the labels. Click Acrobat Reader to download it free.

Why 3 months supply?

click here for administration details.

Click here to view label

Hypericum Perforatum II
Single Order Price:

Note: This is a "one time" purchase. If you would like to continue using this product you will need to manually reorder.

280 tablets

Hypericum Perforatum II
SaverPlan Continuity Program:

Receive a 10% discount with our continuity program and customize your own shipping intervals. ..

Continuity Plan Terms

280 tablets

Click here to view label

Hypericum Perforatum III
with B6 , B12 , and Folic Acid
Single Order Price:

Note: This is a "one time" purchase. If you would like to continue using this product you will need to manually reorder.

280 clear coated/
scored tablets

Hypericum Perforatum III
with B6 , B12 , and Folic Acid
SaverPlan Continuity: Program:
Receive a 10% discount with our continuity program and customize
your own shipping intervals.

Continuity Plan Terms

 280 clear   coated/
scored tablets

St. John's Wort Homeopathic Spray

After two years of exhaustive R&D we are very pleased to announce the release of our, and the world's, first homeopathic St. John's Wort spray. Fast relief for mild to moderate depression.


Wondering if it's ok to take St. John's Wort and 5 HTP?

Articles Information


Personality Quizzes And
Other Miscellaneous Info

Frequently Asked Questions
About St. John's Wort



Children's Corner

Other Nonpharmacologic 
Approaches to Depression


NIH & FDA Warnings and Updates


Clinical Research Studies

Historical St. John's Wort Applications

The historical use of medical St. John's wort is well documented. Commencing 2400 years ago St. John's wort was used as a nerve tonic, a painkiller for arthritis, menstrual cramping, gastrointestinal problems (such as diarrhea, nausea . . . ) as well as ulcers.

The ancient Greeks and Romans used to treat many ailments, including sciatica and poisonous reptile bites as well as to ward against evil spirits, placing sprigs of the plant on statues of their Gods. In fact, the genus name Hypericum is from Greek and means "over an apparition" as the herb was once considered odiferous enough to cause evil spirits to depart.

In the first century St. John’s wort was referred to in Pliny the Elders famous book on natural history for its bracing quality in treating diarrhea and promoting urine flow and bladder troubles.

Dioscorides, a Roman army surgeon, recommended drinking St Johns wort in his medical text, “For it expels choleric excrements…” He also recommended rubbing it on burns. Paracelsus, a medical authority of the Renaissance also wrote of using St. John’s wort to treat wounds. He was also the first to mention using it for psychotic symptoms which he called “phatasmata”.

During medieval times, the Europeans used the plant to treat all forms of madness (They thought St. Johns wort had magical properties) as it blooms near the Summer Solstice. The Saltenitan drug list of the thirteenth century also referred to St. John’s wort as herba demonis fuga--an herb to chase away the devil.

Sixteenth century medical books refers to the plant as Fuga demonum, or devil’s scourge, a term that was repeated frequently in the literature of the next several hundred years.

The oil made from the flowers was listed in the first Pharmacopoeia Londinensis (1618). 1630 Angelo Sala stated that St. John’s wort treated illnesses of the imagination, melancholia, anxiety and disturbances of understanding. He wrote, “St. John’s wort cures these disorders as quick as lightening.” Gerard wrote that its use as a balm for wounds, burns, ulcers and bites was without equal (Gerard 1633).

There is even evidence that the American Indians used St. John's wort used it in the treatment of Tuberculosis and other breathing ailments.

Civil War soldiers collected St. John's wort to use on battle wounds. A prolific and hardy plant that threatened grazing land, a beetle was introduced into the Pacific Northwest in the early 1900's to keep St. John's wort under control.

19th century literature incorporated the use of hypericum to treat melancholia. 19th century British and American literature stressed the superficial use of the herb for the treatment of burns and wounds. A powerful antibacterial, St. John’s wort has been used through the centuries as an analgesic (pain reliever) to treat saddle sores and in poultices for certain lameness's in horses.