Other Names:

Anthemis nobilis, Genuine chamomile, German Chamomile, Hungarian chamomile, Matricaria chamomilla, Roman Chamomile Note: Many different species of chamomile grow throughout the world. The type commonly available in the United States is known as German chamomile (Matricaria chamomilla). It is slightly different from the Roman or English chamomile (Chamaemelum nobilis or Anthemis nobilis) that is more common in Europe. While these two plants belong to different species, they are closely related and both are used for similar conditions.

Uses: In the United States, oral chamomile is used primarily for relaxation and sleep. As chamomile attaches to receptors in the body that are also the targets of prescription sedative medications, low doses produce a calming effect, while higher doses are more likely to cause sleep.

Chamomile also has antispasmodic effects, which means it may relieve or prevent uncomfortable muscle contractions -- especially in the gastrointestinal tract. Therefore, it has also been used to treat minor gastrointestinal complaints such as gas, motion sickness, and stomach cramps. Bisabolol, one of the chemicals in chamomile has shown antispasmodic activity in studies of laboratory animals. A small study of infants with colic showed that a tea containing chamomile and four other herbal ingredients relieved symptoms of colic about twice as often as a liquid with no active ingredients. All the children in the study were over two weeks old.

Chamomile is also thought to have a soothing effect on the tissues inside the mouth, nose, and throat. Sometimes, chamomile is boiled in water and the steam is inhaled to relieve a stuffy nose or congested chest. A chamomile mouthwash has been tested in clinical studies for the relief of mucositis -- painful mouth sores that develop in patients receiving radiation or drug therapy for cancer. Results are conflicting, however. In one study of about 100 cancer patients, a chamomile mouth rinse helped to prevent, delay, or lessen the occurrence of mucositis; but no particular benefit was seen in a later study. More research is needed for all of the potential oral uses of chamomile.

Topically, chamomile can be applied to the skin as a wash or a poultice for hemorrhoids and minor skin irritations. A poultice is usually a soft cloth that has been soaked in a medication, possibly heated, and applied to an aching or injured area of skin surface. Chamomile contains chemicals in a group known as azulenes, which are believed to block the production of histamine by body cells. Histamine is a chemical released in allergic responses. It causes inflammation and muscle spasms. Evidence from laboratory studies shows that chamomile has antibacterial, antifungal, and antiviral properties; but no animal or human studies verify its anti-infective activity.

When should I be careful taking it?

Some evidence shows that chamomile can worsen asthma; therefore, individuals with asthma should avoid using it.

Women who are pregnant should not take chamomile because its antispasmodic effects may relax the uterus, potentially causing a miscarriage.


If chamomile is applied to the skin, it should be kept away from the eyes. To avoid eye irritation, do not touch the eyes if the hands have been used to apply chamomile cream, ointment, salve, wash, or other topical form.

What side effects should I watch for?

When chamomile was taken in extremely high doses, vomiting has been reported.

Multiple cases of skin rash from touching chamomile plants have been reported in the medical literature. Chamomile belongs to the same family of plants as daisies, so individuals who are sensitive to daisies, chrysanthemums, or ragweed may also be sensitive to chamomile.

What interactions should I watch for?

Prescription Drugs

Chamomile contains chemicals that may increase the time blood needs to clot. When it is taken with antiplatelet or anticoagulant drugs, the effect of the antiplatelet or anticoagulant may be increased, resulting in uncontrolled bleeding.

  • Antiplatelet drugs include Plavix and  Ticlid
  • Anticoagulants include heparin and  warfarin
When chamomile is used with prescription drugs that promote sleepiness, the effects of the prescription drug may be exaggerated, resulting in sedation or mental impairment. Prescription drugs that can cause sleepiness include:
  • Anticonvulsants such as carbamazepine  (Tegretol), phenytoin (Dilantin), and valproic acid (Depakote)
  • Barbiturates such as phenobarbital  
  • Benzodiazepines such as alprazolam  (Xanax) and diazepam (Valium)
  • Drugs for insomnia such as zaleplon  (Sonata) and zolpidem (Ambien)
  • Tricyclic antidepressants such as  amitriptyline (Elavil), amoxapine, doxepin and nortriptyline
Chamomile is broken down by certain enzymes in the liver, therefore it may interfere with the use of prescription drugs that are processed by the same enzymes. These drugs may include:
  • Allergy drugs such as fexofenadine  (Seldane)
  • Antifungal drugs such as itraconazole  (Sporanox) and ketoconazole (Nizoral)
  • Cancer drugs such as etoposide  (VePesid), paclitaxel (Onxol, Taxol), vinblastine, or vincristine
  • Drugs for high cholesterol such as  lovastatin (Mevacor)
  • Oral contraceptives
Non-prescription Drugs

Chamomile can affect the ability of blood to clot after. Aspirin can also delay clotting, so chamomile should not be taken at the same time as aspirin.

The sleep-producing effects of over-the-counter products containing diphenhydramine can be enhanced by taking chamomile concurrently. Diphenhydramine is contained in many over-the-counter sleep aids as well as in some cough and cold products, therefore caution should be used when taking these medications with chamomile because excessive drowsiness may result.

Herbal Products

Theoretically, if chamomile is used with other herbs that affect blood clotting, bleeding may occur. The most common herbal products that might inhibit blood clotting include:
  • Danshen
  • Devil's Claw
  • Garlic
  • Ginger
  • Gingko
  • Ginseng
  • Horse Chestnut
  • Papain
  • Red Clover
  • Saw Palmetto
Chamomile may cause excessive sedation if it is taken with other sedating herbs such as:
  • Catnip
  • Hops
  • Kava
  • St. John's Wort
  • Valerian

No interactions between chamomile and foods have been reported, but drinking alcohol when taking chamomile may result in increased drowsiness.

Some interactions between herbal products and medications can be more severe than others. The best way to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals. For specific information on how chamomile interacts with drugs, other herbals, and foods and the severity of those interactions, please use our Drug Interactions Checker to check for possible interactions.

Should I take it?

German Chamomile is native to southern Europe, northern Africa, and parts of Asia, but it now grows in most temperate climates. Its feathery leaves and white, daisy-like flowers appear on annual plants that grow to about two feet in height. The plants spread rapidly -- making them a nuisance weed for farmers and gardeners.

English (Roman) chamomile flowers are very similar to those of German chamomile -- with white petals surrounding a yellow center, but the plants are much different. English chamomile is a ground-covering perennial that seldom grows taller than about one foot. Believed to have originated in northern Europe, it grows in a much more limited area -- primarily the cooler countries of Western Europe.

The flowers of either chamomile species are gathered during the summer when they are blooming. Most commonly, they are dried to be used for medicinal purposes, but chamomile flowers may also be distilled to produce a blue oil. Chamomile is used to flavor foods and also as an ingredient in cosmetics, shampoos, and soap.

Dosage and Administration

Chamomile is usually taken as a tea that can be made by soaking 4 teaspoons of the dried flowers in about 6 ounces of boiling water for about 10 minutes. After the flowers are removed from the liquid, adults may take the warm or cooled tea up to four times a day. In clinical trials, infants were given tea no more than three times a day.

A liquid extract of chamomile is also widely available. Extracts are concentrated liquid preparations usually made by soaking chopped or mashed plant parts in a liquid such as alcohol, and then the solid particles are filtered out. A common dose of chamomile extract is 1mL to 4mL in water three times a day.

For application to the skin, chamomile tea is prepared, cooled and applied as often as needed. In Europe and South America, chamomile creams and ointments are common, but they are not available in the United States.


Chamomile is used mainly to promote relaxation and sleep. It is also used for motion sickness and stomach upset. Applied topically, it soothes irritated tissue.


Because chamomile might make asthma worse, individuals with asthma should not take it. Pregnant and breastfeeding women should also avoid chamomile because of possible negative effects to the fetus and infants . Chamomile should be kept away from the eyes to avoid eye irritation.

Side Effects

Few side effects are associated with taking chamomile, although when it is taken in high doses, vomiting may result.

Individuals allergic to daisies, chrysanthemums or ragweed may also experience allergic reactions to chamomile.


Because it promotes sleepiness, chamomile can increase the sedation associated with certain prescription drugs, non-prescription drugs, and other dietary supplements. Be careful when using it at the same time as you are taking drugs for anxiety, colds and coughs, epilepsy, or insomnia. Many other medications cause drowsiness, so check with your doctor before taking chamomile with any prescription, non-prescription, or herbal product.

Chamomile can also interfere with the way the body breaks down drugs in the liver. You should discuss your other medications with your doctor or pharmacist before you take chamomile.

Last Revised: March 1, 2004


Abebe W. Herbal medication: potential for adverse interactions with analgesic drugs. Journal of Clinical Pharmacy and Therapeutics. 2002;27(6):391-401.

Abramson MJ, Sim MR, Fritschi L, Vincent T, Benke G, Rolland JM. Respiratory disorders and allergies in tea packers. Occupational Medicine (London). 2001;51(4):259-265.

Anon: Chamomile. In: DerMarderosian A, Beutler JA, eds. Facts and Comparisons: The Review of Natural Products. St. Louis, MO, Facts and Comparisons. May 2000.

Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochemistry and Pharmacology. 2000;59(11):1387-1394.

Barene I, Daberte I, Zvirgzdina L, Iriste V. The complex technology on products of German chamomile. Medicina (Kaunas). 2003;39(Suppl 2):127-131.

Blumenthal M, Gruenwald J, Hall T, Rister RS, eds. The Complete German Commission E Monographs. Austin, Texas: American Botanical Council; 1998.

Brinker F. Herb Contraindications and Drug Interactions. Sandy, Oregon: Eclectic Institute, 1997.

Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000;7(4):273-282.

Carl W, Emrich LS. Management of oral mucositis during local radiation and systemic chemotherapy: a study of 98 patients. Journal of Prosthetic Dentistry. 1991;66(3):361-369.

Della Loggia R, Tubaro A, Redaelli C. Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them. [Article in Italian] Riv Neurol. 1981 Sep-Oct;51(5):297-310.

Fidler P, Loprinzi CL, O'Fallon JR, Leitch JM, Lee JK, Hayes DL, et al. Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis. Cancer. 1996;77(3):522-525.

Foster S. Chamomile. 2000. Available at: http://www.stevenfoster.com/education/monograph/chamomile.html Accessed March 6, 2003.

Gardiner P. Chamomile (Matricaria recutita, Anthemis nobilis). The Longwood Herbal Task Force. Date. Available at: http://www.mcp.edu/herbal/chamomile/chamomile.pdf Accessed: February 26, 2004.

Grieve M. Chamomiles. In: A Modern Herbal. New York: Dover Publishers, 1971. Available at: http://www.botanical.com/botanical/mgmh/mgmh.html Posted 1995. Accessed March 1, 2004.

Gyllenhaal C, Merritt SL, Peterson SD, Block KI, Gochenour T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep in Medicine Review. 2000;4(3):229-251.

Hausen BM. A 6-year experience with compositae mix. American Journal of Contact Dermatitis. 1996;7(2):94-99.

Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. American Journal of Health System Pharmacy. 2000;57(13):1221-1230.

Interactive European Network for Industrial Crops and their Applications. Chamomile. Last Updated January 15, 2003. Available at: http://www.ienica.net/crops/chamomile.pdf. Accessed March 1, 2004.

Jellin JM, Gregory P, Batz F, Hitchens K, et al, eds. Pharmacist's Letter/Prescriber's Letter. Natural Medicines Comprehensive Database, 3rd Edition. Stockton CA: Therapeutic Research Facility, 2000.

Kyokong O, Charuluxananan S, Muangmingsuk V, Rodanant O, Subornsug K, Punyasang W. Efficacy of chamomile-extract spray for prevention of post-operative sore throat. Journal of the Medical Association of Thailand. 2002;85 Suppl 1:S180-S185.

McGuffin M, et al, ed. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, 1997.

Miller T, Wittstock U, Lindequist U, Teuscher E. Effects of some components of the essential oil of chamomile, Chamomilla recutita, on histamine release from rat mast cells. Planta Med. 1996;62(1):60-61.

Reider N, Sepp N, Fritsch P, Weinlich G, Jensen-Jarolim E. Anaphylaxis to camomile: clinical features and allergen cross-reactivity. Clinical Experience in Allergy. 2000;30(10):1436-1443.

Rivera JO, Hughes HW, Stuart AG. Herbals and asthma: usage patterns among a border population. Annals of Pharmacotherapy. 2004;38(2):220-225.

Rodriguez-Serna M, Sanchez-Motilla JM, Ramon R, Aliaga A. Allergic and systemic contact dermatitis from Matricaria chamomilla tea. Contact Dermatitis. 1998;39(4):192-193.

Rycroft RJ. Recurrent facial dermatitis from chamomile tea. Contact Dermatitis. 2003;48(4):229.

Safayhi H, Sabieraj J, Sailer ER, Ammon HP. Chamazulene: an antioxidant-type inhibitor of leukotriene B4 formation. Planta Medica. 1994;60(5):410-413.

Schempp CM, Schopf E, Simon JC. Plant induced toxic and allergic dermatitis (phytodermatitis). [article in German]. Hautarzt. Zeitschrift Fuer Dermatologie, Venerologie Und Verwandte Gebiete . 2002;53(2):93-97.

Shipochliev T. Uterotonic action of extracts from a group of medicinal plants. [Article in Bulgarian] Vet Med Nauki. 1981;18(4):94-98.

Simon, J.E., A.F. Chadwick and L.E. Craker. Herbs: An Indexed Bibliography. 1971-1980. The Scientific Literature on Selected Herbs, and Aromatic and Medicinal Plants of the Temperate Zone. Hamden, CT; Archon Books: 1984. Available at: http://www.hort.purdue.edu/newcrop/med-aro/factsheets/CHAMOMILE.html. Accessed March 1, 2004.

Subiza J, Subiza JL, Alonso M, Hinojosa M, Garcia R, Jerez M, Subiza E. Allergic conjunctivitis to chamomile tea. Annals of Allergy. 1990;65(2):127-132.

Subiza J, Subiza JL, Hinojosa M, Garcia R, Jerez M, Valdivieso R, Subiza E. Anaphylactic reaction after the ingestion of chamomile tea: a study of cross-reactivity with other composite pollens. Journal of Allergy and Clinical Immunology. 1989;84(3):353-358.

Viola H, Wasowski C, Levi de Stein M, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Medica. 1995;61(3):213-216.

Weizman Z, Alkrinawi S, Goldfarb D, Bitran C. Efficacy of herbal tea preparation in infantile colic. Journal of Pediatrics. 1993;122(4):650-652.

Wilkinson JM. What do we know about herbal morning sickness treatments? A literature survey. Midwifery. 2000;16(3):224-228.

Last Revised: March 1, 2004