Summary of 25 randomized clinical
studies and tvo drug-monitoring studies on the efficiency of Hypericum
in the treatment of depression and anxiety.
| Authors year |
No of cases |
Total hypericin/day |
Weeks |
Target Parameters |
Test preparation |
Response rate |
Compared treatment |
Resp. rate |
Rating |
| |
|
|
|
|
|
|
|
|
|
| Witte, 1995 |
97 |
0,5 mg x 2 |
6 |
HAMD, D-S |
Psychotonin |
79 % |
Placebo |
56% |
- |
| Ditzler, 1994 |
60 |
0,24 mg x 2 |
8 |
D-S |
Neurapas*** |
67% |
Placebo |
33% |
- |
| Albrecht, 1994 |
1060 |
0,3 mg x 3 |
4 |
HAMD, D-S |
Hypericum
(St. Johns wort)
|
75% |
None |
- |
- |
| Woelk, 1993 |
3250 |
0,9 mg x 3 |
4 |
D-S |
Hypericum
(St. John's wort)
|
82% |
None |
- |
- |
| Sommer,1993 |
105 |
0,9 mg x 3 |
4 |
HAMD |
Hypericum (St. John'w wort) |
67% |
Placebo |
28% |
41 |
| Huebner,1993 |
40 |
0,9 mg x 3 |
4 |
HAMD, B-L,CGI |
Hypericum
(St. John's wort)
|
70% |
Placebo |
47% |
54 |
| Hänsgen, 1993 |
100 |
0,9 mg x 3 |
6 |
HAMD, D-S, CGI, BEB |
Hypericum (St. John's wort) |
81% |
Placebo |
26% |
55 |
| Vorbach, 1993 |
135 |
0,9 mg x 3 |
6 |
HAMD, D-S, CGI |
Hypericum (St. John's wort) |
82% |
Imipramin |
62% |
74 |
| Harrer, 1993 |
102 |
1 mg x 3 |
4 |
HAMD, D-S, CGI |
Hypericum (St. John'w wort) |
61% |
Maprotilin, |
67% |
70 |
| Bergmann, 1993 |
76 |
0,25mg x3 |
6 |
HAMD, Bf-S |
Esbericum |
84% |
Amitryptilin |
74% |
38 |
| Martinez, 1993 |
20 |
0,9 mg x 3 |
4 |
HAMD, (SAD-patients) |
|
60% |
Jarsin + 3000Lux |
72% |
38 |
| König, 1993 |
112 |
0,5-1mg x 2 |
6 |
Bf-S |
Extract Z 90017 |
53% |
Placebo |
53% |
- |
| Lehrl, 1993 |
50 |
0,37 mg x 3 |
4 |
HAMD, KAI |
Hypericum (St. John's wort) |
42% |
Placebo |
25% |
25 |
| Schmidt, 1993 |
65 |
0,37 mg x 3 |
6 |
HAMD, Cognition |
Hypericum
(St John's wort)
|
67% |
Placebo |
26.7% |
- |
| Quandt, 1993 |
88 |
0,37 mg x 3 |
4 |
HAMD |
Psychotonin M |
70,7% |
Placebo |
7,7% |
49 |
| Reh, 1992 |
50 |
0,5mg x 2 |
8 |
HAMD |
Neuroplant |
70% |
Placebo |
45% |
55 |
| Osterheider, 1992 |
46 |
0,25mg x 2 |
8 |
HAMD |
Neuroplant |
0% |
Placebo |
0% |
25 |
| Harrer, 1991 |
116 |
0.37 mg x 3 |
6 |
HAMD, HAMA, D-S |
Psychotonin |
75% |
Placebo |
25% |
52 |
| Halama, 1991 |
50 |
0.3 mg x 3 |
4 |
HAMD, B-L, CGI |
Hypericum
St. John's wort)
|
60% |
Placebo |
12% |
55 |
| Werth, 1989 |
30 |
0,37 mg x 3 |
3,5 |
HAMDafter amputation |
Psychotonin M |
73% |
Imipramin |
60% |
43 |
| Schmidt, 1989 |
40 |
0,37 mg x 3 |
4 |
HAMD , STAI |
Psychotonin M |
65% |
Placebo |
33% |
- |
| Kniebel, 1988 |
130 |
0,1 mg x 2* |
6 |
HAMD, CGI, Bf-S |
Sedariston |
88% |
Amitryptilin |
80% |
35 |
| Schilch, 1987 |
49 |
0,25 mg x 3 |
4 |
HAMD |
Psychotonin M |
28.4% |
Placebo |
-23% |
45 |
| Warnecke, 1986 |
60 |
0,3mg x 2 |
12 |
HAMA, SDS, CGI |
Hyperforat |
77%** |
Diazepam |
50% |
- |
| Steger, 1985 |
93 |
0,1 mg x 2 * |
6 |
CGI, D-S, B-L |
Sedariston |
70% |
Desipramin |
30% |
- |
| Panijel, 1985 |
100 |
0,1 mg x 2* |
2 |
CGI, B-L, STAI |
Sedariston |
78%** |
Diazepam |
54% |
- |
| Hoffmann, 1979 |
60 |
3 mg x 3 |
6 |
Own Scale |
Hypericum
(St. John's wort)
|
61.4% |
Placebo |
15.2% |
16 |
D-S = Depression Scale according to von Zerssen; CGI = Clinical
Global Impression score; B-L = von Zerssen Health Compliant survey; BEB
= Hänsgens complaint inventory; Bf-S = v. Zerssen´s SelfRating Scale;
STAI = State Trait Anxiety Inventory ; KAI = Lehrl's Short Test on
General Information processing; SAD = Seasonal Affective Disorders, SDS
=Self Rating Depression Scale * = + 50 mg Valeriana in
combination-medication. ** Measured by CGI *** combination medication
with Hypericum, Valeria, Passiflorae, Coridalis cavae and Eschscholixiae
californiae.
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