Studies
comparing the antidepressant and anxiolytic effect of hypericum to
synthetic antidepressants
| Authors year |
No |
Substance
Type of study |
Dose |
Hamilton
start / end |
Other
start end |
Resp rate |
Stat. sign. |
Side eff. |
Weeks |
Drop outs |
Inclusion criteria |
| Harrer 1993 |
44 42 |
Hypericum (St. John's Wort)
Maprotilin
|
0,9 mg x 3 25mg x 3 |
20.5 12.2 21.5 10.5 |
26 16 25 DS 14 |
61% 67% |
No sign |
25% 35% |
4 |
17% 21% |
ICD 10 F32.1 |
| Bergmann 1993 |
· 32 28 |
Esbericum Amitryptilin RCT |
0,25mg x3 10mg x 3 |
15.82 6.34 15.26 6.65 |
31.4 24,.2 28.2 DS 24.1 |
84% 74% |
No sign |
24% 58% |
6 |
7% 7% |
ICD 10 F32.0, F32.1 F33.0, F33.1 |
| Vorbach 1993 |
67 68 |
Hypericum (St. John's Wort)
Imipramin
|
0,9 mg x 3 25mg x 3 |
20.2 8.8 19.4 10.7 |
1.3 3.1 1.2 CGI 2.7 |
82% 62% |
No sign |
12% 16% |
6 |
1,5% 6% |
DSM III R, 296.2 296.3. 300.4 309.0 |
| same |
26 25 |
same as above |
same as above |
25 9 24 14 |
_ |
_ |
p< 0.05 |
_ |
6 |
_ |
HAMD > 21 |
| Werth, 1989 |
15 15 |
Psychotonin Imipramin |
0,37mgx3 50 mg x 3 |
24,5 5,0 26,7 4,7 |
1,5 2,8 1,8 CGI 2,5 |
73% 60% |
No sign |
7% 20% |
3,5 |
0% 6,7% |
Before and after leg amputation |
| Kniebel, 1988 |
65 65 |
Sedariston Amitryptilin |
0,1mg x 2* 25 mg x 3 |
23,7 5,9 24,3 7,9 |
45 16 45 DS 22 |
88% 80% |
p< 0,0001 |
10% 50% |
6 |
1,5% 1,5% |
ICD 09 309,0. 309,1 300,5. 300,4 |
| Warnecke 1986 |
40 20 |
Hypericum (St.John's Wort)Diazepam |
0,2 mg x 3 2 mg x 3 |
3,6 2,0 3,8 SDS 2,6 |
2,8 0,79 3,0 HAMA 1,9 |
77,5% 50,0% |
not made |
no serious |
12 |
0% 0% |
"climacteric depressions" |
| Panijel, 1985 |
50 50 |
Sedariston Diazepam |
0,1-0,2mg x 2* 2--4mg x 2 |
44,0 11,5 40,0 B-L 22,5 |
75,5 39,5 75,5 STAI 53,5 |
78%*** 54%*** |
p< 0,0007 |
4% 14% |
2 |
0% 0% |
moderate anxiety syndrome |
| Steger, 1985 |
93 to-tal |
Sedariston Desipramine |
0,1mg x 2* 100 mg/day** |
1.0 1,9 1,0 CGI 0,8 |
25 7 27 DS 19 |
70% 30% |
p< 0,0021 |
no detail |
6 |
0% 0% |
light to moderate depressions |
|
