HBC Protocols

Studies comparing the antidepressant and anxiolytic effect of hypericum to synthetic antidepressants

Authors year	No	Substance Type of study	Dose	Hamilton start / end	Other start end	Resp rate	Stat. sign.	Side eff.	Weeks	Drop outs	Inclusion criteria
Harrer 1993	44 42	Hypericum (St. John's Wort) Maprotilin	0,9 mg x 3 25mg x 3	20.5 12.2 21.5 10.5	26 16 25 DS 14	61% 67%	No sign	25% 35%	4	17% 21%	ICD 10 F32.1
Bergmann 1993	· 32 28	Esbericum Amitryptilin RCT	0,25mg x3 10mg x 3	15.82 6.34 15.26 6.65	31.4 24,.2 28.2 DS 24.1	84% 74%	No sign	24% 58%	6	7% 7%	ICD 10 F32.0, F32.1 F33.0, F33.1
Vorbach 1993	67 68	Hypericum (St. John's Wort) Imipramin	0,9 mg x 3 25mg x 3	20.2 8.8 19.4 10.7	1.3 3.1 1.2 CGI 2.7	82% 62%	No sign	12% 16%	6	1,5% 6%	DSM III R, 296.2 296.3. 300.4 309.0
same	26 25	same as above	same as above	25 9 24 14	_	_	p< 0.05	_	6	_	HAMD > 21
Werth, 1989	15 15	Psychotonin Imipramin	0,37mgx3 50 mg x 3	24,5 5,0 26,7 4,7	1,5 2,8 1,8 CGI 2,5	73% 60%	No sign	7% 20%	3,5	0% 6,7%	Before and after leg amputation
Kniebel, 1988	65 65	Sedariston Amitryptilin	0,1mg x 2* 25 mg x 3	23,7 5,9 24,3 7,9	45 16 45 DS 22	88% 80%	p< 0,0001	10% 50%	6	1,5% 1,5%	ICD 09 309,0. 309,1 300,5. 300,4
Warnecke 1986	40 20	Hypericum (St.John's Wort)Diazepam	0,2 mg x 3 2 mg x 3	3,6 2,0 3,8 SDS 2,6	2,8 0,79 3,0 HAMA 1,9	77,5% 50,0%	not made	no serious	12	0% 0%	"climacteric depressions"
Panijel, 1985	50 50	Sedariston Diazepam	0,1-0,2mg x 2* 2--4mg x 2	44,0 11,5 40,0 B-L 22,5	75,5 39,5 75,5 STAI 53,5	78%* 54%*	p< 0,0007	4% 14%	2	0% 0%	moderate anxiety syndrome
Steger, 1985	93 to-tal	Sedariston Desipramine	0,1mg x 2* 100 mg/day**	1.0 1,9 1,0 CGI 0,8	25 7 27 DS 19	70% 30%	p< 0,0021	no detail	6	0% 0%	light to moderate depressions

·DS = Depression Scale according to von Zerssen, self-rating, CGI = Clinical Global Impression score, HS = von Zerssen Health Complaint survey BEB = Symtom complaint inventory, STAI = State Trait Anxiety Inventory, B-L = Beschwerden Liste (Complaqint Inventory) according to von Zerssen, SDS =Self Rating Depression Scale , * + 50 mg Valeria, ** First week 150 mg daily, *** Response rate measured by STAI.

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