Summary of
studies on Hypericum Vs Placebo
| Authors year |
No |
Substance |
Dose |
Hamilton
start end |
Other
start end |
Resp rate |
Stat. sign. |
Side eff. |
Weeks |
Drop outs |
Inclusion criteria |
Witte
1995 |
48
49 |
Psychotonin
Placebo |
0,5 mg x2 |
24.6 7.9
23 12 |
25 8
21 DS 12 |
79 %
56% |
p<
0.02 |
0
0 |
6 |
21%
total |
ICD10 F32.1 |
| Ditzler 1994 |
30
30 |
Nerapas*
Placebo |
0,24mgx3* |
15,3 7,3
18,4 DS 12,0 |
55,7 38,4
56,8 DSI 3,9 |
67%
33% |
p< 0,01 |
No
diff |
8 |
3%
0% |
DSM -III-R, major depression, |
Sommer
1993 |
42
47 |
St. John's wort
Placebo |
0,9 mg x 3 |
15.8 7.2
15.8 11,.3 |
_ |
67%
28% |
p<
0.01 |
No
diff |
4 |
4%
14% |
ICD 09 300.4 309.0 |
Hubner
1993 |
20
19 |
St. John's wort
Placebo |
0,9 mg x 3 |
12.5 5
12.4 11 |
15.8 6.8
16.7 HS 16.9 |
70%
47% |
p<
0.05 |
No diff |
4 |
_ |
ICD 09 300.4 309.0 |
| König 1993 |
55
57 |
extr. Z 90017
Placebo |
0,5-1 mgx2 |
34,7 20,8
34,3 B-S 21,1 |
64,1 48,2
64,7 DSI 50,6 |
53%
53% |
no diff |
22%
28% |
6 |
24%
26% |
Psychoaff. disorders with depressed mood |
Hänsgen
1993 |
33
34 |
St. John's wort
Placebo |
0,9 mg x 3 |
21.8 6
20.4 14 |
131 77
127 BEB 104 |
81%
26% |
p<
0.001 |
6%
3% |
6 |
3%
12% |
DSM III R
major depression |
| Lehrl 1993 |
25
25 |
St. John's wort
Placebo |
0,37mg x 3 |
23,7 17,4
21,6 16,8 |
39,7 34,5
41,2 KAI 37,7 |
42%
25% |
no diff |
|
4 |
?
? |
ICD 09 300,4
309,0 |
Schmidt
1993 |
32
33 |
St. John's wort
Placebo |
0.9 mg x 3 |
? ?
? ? |
No cognitive problems |
67%
27% |
p<
0.01 |
7%
10% |
6 |
0% |
ICD 09 300,4
309,0 |
Martinez
1993 |
10
10 |
St. John's wort
+ light therapy |
300 Lux
3000 Lux |
20.6 8.2
21.9 6.1 |
_ |
_ |
No
sign |
0%
0% |
4 |
0% |
DSM III R
SAD |
| Quandt, 1993 |
88 |
Psychotonin
Placebo |
0,37mg x3 |
17.8 9.8
17.3 16.6 |
- |
71%
7,7% |
p<
0.001 |
0%
0% |
4 |
? |
ICD 09
300.4 |
| Osterheider 1992 |
22
2 |
Psychotonin
Placebo |
0,25mg x 3 |
? ?
? ? |
? ?
? ? |
0%
0% |
No diff |
? |
8 |
? |
Unspecified
Depression |
Reh,
1992 |
25
25 |
Neuroplant
Placebo |
0,5 mg x 2 |
19 8
20 14 |
30 9
32 D-S 22 |
80%
44% |
p< 0,02 |
0%
0% |
8 |
0%
0% |
ICD 09 300.4
309.0 311.0 |
Harrer
1991 |
58
58 |
Psychotonin
Placebo |
0,37mg x 3 |
21,6 8,9
20,9 16,1 |
11,9 4,5
12,1 HAMA 8,2 |
75%
25% |
p<
0,001 |
2%
0% |
6 |
6,4%
1,8% |
ICD 9 304,4
309,9 |
Halama
1991 |
25
25 |
St. Johns
Placebo |
0,37 mg |
18,0 10.0
17,5 18,0 |
30.0 12,5
30,0 B-L 29,5 |
50%
0% |
p<
0,005 |
4 %
0 % |
4 |
0%
0% |
ICD 09 300,4
309,0 |
Schmidt
1989 |
16
12 |
St.John's
Placebo |
0,37mgx3 |
29,2 9,7
29,5 19,5 |
64.2 51,9
60,3 STAI 53,1 |
62,%
33,% |
p<
0,01 |
0%
0% |
4 |
0%
0% |
ICD 09 290,2. 296,1 298,0. 300,0 300,4 |
Schlich
1987 |
22
24 |
Psychotonin
Placebo |
0,25mgx3 |
22,9 16,4
24,0 29,6 |
60,9 19,7
61,6 55,3 |
68%
10% |
p<
0,05 |
0%
0% |
4 |
6%
total |
Unspecified depression |
Hoffman
1979 |
30
30 |
Hypericum
Placebo |
0,3mg x 3 |
- |
1,76 own 0,68
1,83 scale 1,54 |
61%
16% |
not
made |
0%
0% |
6 |
0%
0% |
mild to moderate
depression |
D-S = Depression Scale according to von Zerssen, self-rating, CGI
= Clinical Global Impression score, HS = von Zerssen Health
Complaint survey, BEB = Symtom complaint inventory, STAI = State
Trait Anxiety Inventory, B-L = Beschwerden Liste (Complaint
Inventory) according to von Zerssen, HAMA = Hamilton Anxiety
scale, DSI = Depression Status Inventory * combination medication
with Hypericum, Valeria, Passiflorae, Coridalis cavae and
Eschscholixiae californiae
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